Evolución de la leucemia linfoblástica aguda en la edad pediátrica en 29 años ( )Outcome of acute lymphoblastic leukemia in the pediatric age group . La leucemia linfoblástica aguda (LLA) es el cáncer más común en los niños y está entre los más curables de las malignidades pediátricas. El análisis citogenético de las células blásticas en niños con leucemia linfoblástica aguda (LLA) ha permitido el reconocimiento de alteraciones cromosómicas.

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Leucemia linfoblástica aguda en pacientes portadores de síndrome de Down

Biology and clinical significance of cytogenetic abnormalities in childhood acute lymphoblastic leukemia. Cytogenetic and molecular studies of Down syndrome individuals with leukemia.

Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias. Cancer, 40pp. J Pediatr ; Br J Haematol, 43pp. Current status of cytogenetic research in childhood acute lymphoblastic leukemia.

Clinical characteristics and treatment outcome of children with acute lymphocytic leukemia and Down’s syndrome. Clinical and biological characteristics of acute lymphocytic leukemia in children with Down syndrome. This study focuses on the most important chromosomal abnormalities found in childhood ALL and their prognostic and therapeutic implications.


Proposal for the immunological classification of acute leukemias. Br J Haematol, 90pp. Nondisjunction of chromosomes leading to hyperdiploid chilhood B-cell precursor acute lymphoblastic leukemia is an early event during leukemogenesis. Cytogenetic abnormalities in childhood acute lymphoblastic leukemia correlates with clinical features and treatmentoutcome. Rev Chil Pediatr ; 83 1: Cytogenetic analysis of blast cells in childhood acute lymphoblastic leukemia has led to the recognition of specific non-random chromosomal abnormalities with prognostic value.

Blood, 75pp. Methotrexate-induced side effects are not due to differences in pharmacokinetics in children with Down syndrome and acute lymphoblastic leukemia. Blood, 81pp.

Results of an in vitro study. En la tabla 3 se muestran las distintas fases de tratamiento utilizadas.

Alteraciones cromosómicas en la leucemia linfoblástica aguda | Anales de Pediatría

Acute lymphoblastic leukemia and high hyperdiploidy in children. Formation of a Hyperdiploid Karyotype in childhood acute Lymphoblastic Leukemia. Abnormal serum IgG subclass pattern in children with Limfoblastica syndrome. Translocation 12;22 p13;q11 in myeloproliferative disorders results in fusion of the ETS-like Tel gene on 12p13 to the MN1 gene on 22q Leukemia, 7pp.


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The greatest impact on patient management has been the finding that the cytogenetic result is an independent prognostic indicator. Genes Chromosom Cancer, 9pp. Leukemia ; These patients can be lincoblastica with the current trials but they require a detailed infection care.

Hyperdiploid acute lymphoblastic leukemia in children. Sangre, 44pp. Mol Cell Biol, 14pp.

Prognostic implications of chromosomal findings in acute lymphoblastic leukemia at diagnosis. Blood, 79pp. Trisomy of leukemic cell chromosomes 4 and 10 identifies children with B-progenitor cell acute lymphoblastic oeucemia with a very low risk of treatment failure. Localization the estrogen receptor locus ESR to chromosome 6q Hospital Higueras Talcahuano, Drs: